Unexpected effect of testosterone in hypergonadotropic hypogonadism and nodular Leydig cell hiperplasia. Report of one case

We report a 27 -year-old male referred because of hypergonadotropic hypogonadism with low testosterone and azoospermia. At 23 years age, he underwent an excision hypoechoic 0.7 cm nodule the left testicle. The pathological diagnosis was Leydig cell tumor. In right testicle, there were three nodules at ultrasound, biggest measuring 0.6 cm. Four later, in testicle still present larger excised. biopsy showed tubules only Sertoli cells perinodular zone. Diffuse nodular hyperplasia found interstitium. syndrome severe cells. With therapy, LH decreased, disappeared. Thereafter, upon interrupting increased, reappeared two occasions. Resuming treatment, disappeared again, suggesting dependent on chronic stimulation.